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three is not really within an open up conformation. This acquiring, having said that, will not exclude the likelihood that other conformational modifications have taken area or the existence of two successive proline residues improves the pliability on the PSI/hybrid domains, As a result facilitating extension and opening on the α
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13 activation as a result of PAR4 stimulation is linked to the spreading of WT samples and could dampen constitutively activated Src in KI mice, as recommended by the significant statistical drug by genotype interactions from the existence of PAR4-AP.
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three to interact with intracellular proteins. Simply because talin binding is step one involved with integrin activation, we examined coimmunoprecipitation of talin and α
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